http://www.youtube.com/watch?v=lVlgMEFu1PI#ws... и добавил:http://examine.com/supplements/Marijuana/... и добавил: A reduction in motivation seen in chronic cannabis use may be associated with a reduction in dopamine synthesis.
... и добавил:от гашиша уменьшаются яйца
Bhang (leaf/flower extract of Cannabis sativa with over 25% Δ9THC content) orally at 3-6mg/kg daily in mice for 36 days has been noted to reduce testicular weight in a dose-dependent manner by 14-27%. This was associated with a reduction in 3βHSD and FAAH activity alongside reduced serum testosterone, thought to be related to testicular toxicity as assessed by histology.[4]
... и добавил:Oral ingestion of 3-6mg/kg bodyweight liquid Bhang (aqueous Cannabis Sativa) is able to dose-dependently decrease testicle weight in rats over 36 days, by 17% at 3mg/kg and 33% at 6mg/kg.[4]
14.2. Spermatogenesis
Histologically, an absence of spermatozoa has been seen after oral administration of 3-6mg/kg Bhang ingestion in up to 40% of tubules observed.[4] Spermatozoa apoptosis (sperm death) appeared to increase as observed via staining.[4]
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A reduction in CB1 receptor availability has been noted in chronic marijuana users. This reduction in CB1 availability is normalized after four weeks abstinence.
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Symptoms of marijuana withdrawal include difficulties with sleep, restlessness, decreased appetite, depressed mood, nervousness or anxiety, irritability, and physical symptoms/discomfort; at least three of the aforementioned seven would be present for a diagnosis of cannabis withdrawal syndrome (DSM-V).[656]
Physical symptoms refer to symptoms such as stomach pain, shakiness, sweating, chills, and/or headaches but are generally less frequently reported than other symptoms.[657] Major psychological withdrawal symptoms include decreased appetite, difficulty sleeping, irratibility and anger, strange dreams, restlessness, and marijuana cravings.[658][651] The time course of these symptoms can vary significantly.[659][651]
Marijuana withdrawal lasts for approximately a week to a month. The symptoms are both physical and mental, with physical symptoms being less prevalent. Major symptoms include insomnia and trouble sleeping, restlessness, irratibility, change in appetite, alongside cravings for marijuana.
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Marijuana dependence was defined in the DSM IV-TR as having 3 or more of the following symptoms occuring at any time during the same 12-month period: tolerance, taking marijuana in larger amounts or longer than intended, having a desire to or unsuccessful attempts at reducing use, spending a lot of time obtaining the drug or using or recovering from its use, continued use despite being aware of its adverse consequences, and giving up important activities because of use.[670] By these criteria, approximately 4.3 percent of Americans have been dependent on marijuana at some point in their lives.[671] However, a newer edition, the DSM V, has eliminated this specific category of dependence and replaced it with a substance use disorder category[670] as well as a specifically recognized cannabis withdrawal syndrome.[659]
... и добавил:но видимо зависимость не такая мощная как от остальной наркоты
Neurobiologically, a classical sign of dependency in the brain, a reduction in dopamine signalling in the striatum and local brain regions, does not appear to extend to marijuana despite most other common drugs of abuse sharing this mechanism.
... и добавил:возможно может спровоцировать инфаркт или типа того
There have been a few case studies of youth with no history of cardiovascular problems experience nonlethal[682] and lethal[683][684] heart attacks (from coronary thrombosis) associated with marijuana usage, and other various coronary syndromes,[685][686] strokes, [687]and combine cerebral and myocardial infarctions.[688] In some cases symptoms have arisen near the time of marijuana ingestion which at least suggests a causal link,[682][689][690][691][691] It has been hypothesized that marijuana inhalation may serve as an acute 'trigger' exacerbating previously existing symptoms (which were initially benign)[689][691] although at times adverse effects have also been seen in people with no prior known symptoms or complications.[691]
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